Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.58 |
| ▸ | USP2 | O75604 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.53 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8479321 | 0.91 | MEN1 (0.85) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| Hydrochloric Acid SCHEMBL11455379 | 0.89 | MEN1 (0.82) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| SCHEMBL5267415 | 0.87 | CYP2D6 (0.68) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| Hydrochloric Acid SCHEMBL31327366 | 0.85 | CYP2D6 (0.65) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| SCHEMBL2054235 | 0.84 | CYP2D6 (0.67) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| SCHEMBL2794662 | 0.83 | MEN1 (1.00) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| SCHEMBL219432 | 0.83 | MEN1 (1.00) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| Hydrochloric Acid SCHEMBL16107427 | 0.82 | CYP2D6 (0.64) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| SCHEMBL5363117 | 0.82 | CYP2D6 (0.76) | KMT2AMEN1CYP2C9CYP2C19USP2 | |
| Hydrochloric Acid SCHEMBL7006476 | 0.81 | MEN1 (0.96) | KMT2AMEN1CYP2C9CYP2C19USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260185-A1 | 2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD) | CHRONOS THERAPEUTICS LIMITED (GB) | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260185-A1 | 2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD) | SLC6A3, SLC6A4, SLC6A2 | KMT2A 644/4885MEN1 3418/4885CYP2C9 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.