SCHEMBL19360491

SCHEMBL19360491

CCS(=O)(=O)c1ccc(CNC(=O)c2cc3cc(Cc4ccc(Cl)cc4C(F)(F)F)n(CCF)c3cc2F)cc1

nearest known ligand 0.79

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 18/20 0.79
DDR1 Q08345 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28797801 0.94 RORC (0.70) RORCDDR1
SCHEMBL19360500 0.90 RORC (0.64) RORC
SCHEMBL28797797 0.90 RORC (0.65) RORCDDR1
SCHEMBL19360524 0.89 RORC (0.62) RORCDDR1
SCHEMBL19360547 0.88 RORC (1.00) RORC
SCHEMBL28797791 0.87 RORC (0.62) RORC
SCHEMBL29654173 0.87 RORC (0.62) RORC
SCHEMBL20635529 0.86 RORC (0.80) RORC
SCHEMBL21877839 0.86 RORC (0.80) RORC
SCHEMBL28797805 0.82 RORC (0.89) RORCDDR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107531679-B Aromatic amide derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2021-07-02 CN disclosed
WO-2017157332-A1 AROMATIC AMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATIONS THEREOF 江苏恒瑞医药股份有限公司 2017-09-21 WO disclosed