SCHEMBL28797797

SCHEMBL28797797

CCS(=O)(=O)c1ccc(CNC(=O)c2cc3cc(Cc4ccc(Cl)cc4C(F)(F)F)n(CCOC(F)F)c3cc2F)cc1

nearest known ligand 0.65

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 18/20 0.65
DDR1 Q08345 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28797801 0.90 RORC (0.70) RORCDDR1
SCHEMBL19360491 0.90 RORC (0.79) RORCDDR1
SCHEMBL28797809 0.89 RORC (0.82) RORC
SCHEMBL29654173 0.83 RORC (0.62) RORC
SCHEMBL28797791 0.83 RORC (0.62) RORC
SCHEMBL28797828 0.82 RORC (0.86) RORC
SCHEMBL19360500 0.81 RORC (0.64) RORC
SCHEMBL19360524 0.80 RORC (0.62) RORCDDR1
SCHEMBL28797805 0.79 RORC (0.89) RORCDDR1
SCHEMBL19360547 0.79 RORC (1.00) RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109485595-B Hydrophilic group substituted indole formamide derivative, preparation method and medical application thereof 江苏恒瑞医药股份有限公司 2022-05-27 CN disclosed