Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.35 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.34 |
| ▸ | ITGAL | P20701 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618681 | 0.90 | KARS1 (0.35) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618689 | 0.90 | KARS1 (0.35) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618646 | 0.88 | PIM2 (0.33) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618657 | 0.88 | KARS1 (0.42) | KARS1LRRK2 | |
| SCHEMBL17618680 | 0.88 | KARS1 (0.42) | KARS1LRRK2 | |
| SCHEMBL17618666 | 0.87 | KARS1 (0.41) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL19669052 | 0.87 | KARS1 (0.41) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618688 | 0.85 | SCD (0.38) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618679 | 0.85 | SCD (0.38) | KARS1ITGB2ICAM1ITGALLRRK2 | |
| SCHEMBL17618648 | 0.83 | FAAH (0.37) | KARS1ITGB2ICAM1ITGALCSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |