Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618735 | 0.95 | LMNA (0.30) | — | |
| SCHEMBL19669056 | 0.77 | CA1 (0.52) | — | |
| SCHEMBL19669980 | 0.75 | CA1 (0.51) | — | |
| SCHEMBL19365748 | 0.75 | CA1 (0.51) | — | |
| SCHEMBL19365512 | 0.75 | — | — | |
| SCHEMBL19862439 | 0.74 | KMT2A (0.41) | — | |
| SCHEMBL16754369 | 0.73 | IDH2 (0.41) | — | |
| SCHEMBL16250003 | 0.71 | CA2 (0.42) | — | |
| SCHEMBL17618888 | 0.71 | NAMPT (0.42) | — | |
| SCHEMBL16249987 | 0.71 | KDM4E (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |