Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL4370506 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1617251 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL241885 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL6046437 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL6046435 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1617625 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL6046494 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1247518 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL3283790 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL19210022 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117736153-A | Phenazine derivative, method for producing the same, electron mediator, and sensor | 南京晶捷生物科技有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-109592768-B | Preparation method of embedded algae treating agent for domestic sewage | 山东大湖新材料有限公司 | 2021-12-24 | — | — | CN | claimed |
| CN-108658503-B | Preparation method of concrete air entraining agent | 浙江龙游通衢建材有限公司 | 2021-01-08 | — | — | CN | claimed |
| CN-108467280-B | Heat preservation and insulation material for solar energy | 浙江特圣建材有限公司 | 2020-11-20 | — | — | CN | claimed |
| CN-108359380-B | Preparation method of emulsion type automobile polishing wax | 玉环市粢醍化妆品有限公司 | 2020-10-09 | — | — | CN | claimed |
| CN-110201603-A | Novel Cationic Surfactants and preparation method thereof | 湖南华腾制药有限公司 | 2019-09-06 | — | — | CN | claimed |
| CN-109796407-A | A kind of modularization prepares the method and application of chemical small molecule probe | 鼎元(天津)生物医药科技有限公司 | 2019-05-24 | — | — | CN | claimed |
| CN-103932464-B | The bleaching processing method of fresh water pearl | PURE PEARL GROUP CO., LTD. (CN) | 2015-09-30 | — | — | CN | claimed |
| CN-103932464-A | Bleaching processing method of fresh water pearl | PURE PEARL GROUP CO LTD | 2014-07-23 | — | — | CN | claimed |
| CN-103554482-A | Method for synthesizing hydroxyl-terminated polyethylene glycol p-toluenesulfonate | XIAN MODERN CHEMISTRY RES INST | 2014-02-05 | — | — | CN | claimed |
| CN-1257886-A | Process for synthesizing polyether p-toluenesulfonate | CHENGDU ORGANIC CHEM INST (CN) | 2000-06-28 | — | — | CN | claimed |
| CN-118240199-A | Binuclear copper complex based on alkyne palladium ligand and preparation method thereof | 安徽大学 | 2024-06-25 | — | — | CN | disclosed |
| CN-117924203-A | Method for synthesizing ozagrel intermediate | 山东新时代药业有限公司 | 2024-04-26 | — | — | CN | disclosed |
| CN-117736153-A | Phenazine derivative, method for producing the same, electron mediator, and sensor | 南京晶捷生物科技有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-117186450-A | Polyether functionalized ionic gel and preparation method and application thereof | 北京化工大学 | 2023-12-08 | — | — | CN | disclosed |
| US-4943502-A | TWO LAYER SYSTEM OF CHARGE GENERATING AND CHARGE TRANSPORTING COMPOUNDS | AGFA-GEVAERT, N.V. (BE) | 1990-07-24 | — | — | US | disclosed |
| EP-0347960-A1 | Photosensitive recording material suited for use in electrophotography | AGFA-GEVAERT N.V. (BE) | 1989-12-27 | — | — | EP | disclosed |
| EP-0347967-A1 | Photosensitive recording material suited for use in electrophotography | AGFA-GEVAERT N.V. (BE) | 1989-12-27 | — | — | EP | disclosed |
| US-4311541-A | COMPRESSING MOLDING, FOAMING RESOLE TO ENCAPSULATE EXPANDED THERMOPLASTIC RESIN | THE DOW CHEMICAL CO. (US) | 1982-01-19 | — | — | US | disclosed |
| US-4233361-A | EXPANDED THERMOPLASTIC PARTICLES AND GLASS PARTICLES ENCAPSULATED WITHIN A RESOLE RESIN FOAM | THE DOW CHEMICAL COMPANY (US) | 1980-11-11 | — | — | US | disclosed |