Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ethylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | SNCA | P37840 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | MMP13 | P45452 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL4370506 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1617251 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL241885 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL6046437 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1617625 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1936216 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL6046494 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL1247518 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL3283790 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E | |
| Ethylene Glycol SCHEMBL19210022 | 1.00 | GAA (0.52) | GAAALDH1A1SMN1; SMN2LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060240443-A1 | Microarray-based single nucleotide polymorphism, sequencing, and gene expression assay method | COMBIMATRIX CORPORATION | 2006-10-26 | — | — | US | disclosed |