SCHEMBL1936374

SCHEMBL1936374

CCN(OC(C)=O)C(=O)OC(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.39
HDAC1 Q13547 1/20 0.39
HDAC2 Q92769 1/20 0.39
GAA P10253 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.32
NFKB1 P19838 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
CA14 Q9ULX7 2/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA7 P43166 1/20 0.32
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
MAPT P10636 1/20 0.31
RAB9A P51151 1/20 0.31
ALDH1A1 P00352 2/20 0.30
KMT2A Q03164 1/20 0.30
LMNA P02545 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9171625 0.84 HDAC6 (0.50) HDAC6HDAC1HDAC2L3MBTL1NFKB1
SCHEMBL15488438 0.79 HDAC6 (0.37) HDAC6HDAC1HDAC2GAAL3MBTL1
SCHEMBL24186853 0.79 HDAC6 (0.37) HDAC6HDAC1HDAC2L3MBTL1NFKB1
SCHEMBL20496118 0.78 HDAC6 (0.36) HDAC6HDAC1HDAC2L3MBTL1KDM4E
SCHEMBL7493210 0.78 CA14 (0.35) HDAC6HDAC1HDAC2GAACA14
SCHEMBL14894156 0.78 HDAC6 (0.36) HDAC6HDAC1HDAC2L3MBTL1
SCHEMBL18405549 0.78 HDAC6 (0.38) HDAC6HDAC1HDAC2L3MBTL1CA14
SCHEMBL1562708 0.78 HDAC6 (0.38) HDAC6HDAC1HDAC2L3MBTL1NFKB1
SCHEMBL28644440 0.78 HDAC6 (0.40) HDAC6HDAC1HDAC2L3MBTL1NFKB1
SCHEMBL2232464 0.77 ALDH1A1 (0.50) GAAL3MBTL1CA12CA1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1444225-B1 PYRROLIDINE OXADIAZOLE- AND THIADIAZOLE OXIME DERIVATIVES BEING OXYTOCIN RECEPTOR ANTAGONISTS. MERCK SERONO SA (CH) 2012-10-10 EP disclosed
EP-2331518-A1 NEW BRADYKININ B1 ANTAGONISTS Evotec AG (DE) 2011-06-15 EP disclosed