Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 13/20 | 0.64 |
| ▸ | EPX | P11678 | 1/20 | 0.43 |
| ▸ | TPO | P07202 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19363910 | 0.93 | MPO (0.74) | MPOEPXTPO | |
| SCHEMBL19363911 | 0.78 | MPO (0.78) | MPOEPXTPO | |
| SCHEMBL19381400 | 0.77 | MPO (0.57) | MPOEPXTPO | |
| SCHEMBL19363796 | 0.77 | MPO (0.54) | MPOEPXTPOOPRM1OPRD1 | |
| SCHEMBL22433098 | 0.76 | MPO (0.56) | MPOEPXTPOOPRM1OPRD1 | |
| SCHEMBL19363797 | 0.70 | MPO (0.49) | MPOEPXOPRM1OPRD1OPRK1 | |
| SCHEMBL19364095 | 0.69 | MPO (0.55) | MPO | |
| SCHEMBL19363914 | 0.69 | MPO (0.79) | MPO | |
| SCHEMBL19358433 | 0.67 | MPO (0.68) | MPOEPX | |
| SCHEMBL19380881 | 0.66 | MPO (0.46) | MPOTPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017160632-A1 | TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-09-21 | — | — | WO | disclosed |