Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 4/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19364791 | 0.89 | KDM4E (0.43) | KDM4EADCY1TDP1LMNAL3MBTL1 | |
| SCHEMBL19365661 | 0.81 | MEN1 (0.39) | TLR8MEN1KMT2A | |
| SCHEMBL19365846 | 0.78 | TLR8 (0.41) | TLR8 | |
| SCHEMBL19365544 | 0.78 | TLR8 (0.41) | LMNAHTTMAPTTLR8ALDH1A1 | |
| SCHEMBL19364780 | 0.78 | EPHB4 (0.41) | MAPTTLR8 | |
| SCHEMBL19670424 | 0.78 | MAPK14 (0.37) | TLR8ABL1PDGFRBSRCPDGFRA | |
| SCHEMBL19670314 | 0.77 | CA1 (0.49) | PTGS2LMNASMN1; SMN2HTTMAPT | |
| SCHEMBL19365825 | 0.77 | MCHR1 (0.40) | TLR8 | |
| SCHEMBL19364790 | 0.76 | TLR8 (0.42) | KDM4ELMNAMAPTTLR8ALDH1A1 | |
| SCHEMBL20632399 | 0.76 | TLR8 (0.41) | TLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |