Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 4/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 2/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | RHOA | P61586 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365619 | 0.83 | KMO (0.37) | MAPK14BRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365786 | 0.81 | RHOA (0.37) | MAPK14BRAFPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19364780 | 0.78 | EPHB4 (0.41) | TLR8PIK3CDPIK3CAPIK3CGEPHB4 | |
| SCHEMBL20632322 | 0.78 | ALOX15 (0.41) | MAPK14TLR8PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19364794 | 0.78 | KDM4E (0.41) | TLR8ABL1PDGFRBSRCPDGFRA | |
| SCHEMBL19365544 | 0.77 | TLR8 (0.41) | TLR8EPHB4 | |
| SCHEMBL19365846 | 0.77 | TLR8 (0.41) | TLR8PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19364791 | 0.76 | KDM4E (0.43) | TLR8PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19365825 | 0.76 | MCHR1 (0.40) | TLR8PIK3CDPIK3CAPIK3CGKMO | |
| SCHEMBL19670314 | 0.76 | CA1 (0.49) | TLR8CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |