Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670317 | 1.00 | DYRK1A (0.42) | DYRK1AGSK3BSYKALDH1A1SMN1; SMN2 | |
| SCHEMBL19365399 | 0.89 | PRMT5 (0.40) | DYRK1AGSK3BALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19365398 | 0.89 | PRMT5 (0.40) | DYRK1AGSK3BALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL19670325 | 0.87 | GSK3B (0.39) | DYRK1AGSK3BCYP3A4 | |
| SCHEMBL19365582 | 0.87 | GSK3B (0.39) | DYRK1AGSK3BCYP3A4 | |
| SCHEMBL19365402 | 0.86 | PIK3C3 (0.42) | DYRK1AGSK3BLMNANPC1RAB9A | |
| SCHEMBL19365403 | 0.86 | PIK3C3 (0.42) | DYRK1AGSK3BLMNANPC1RAB9A | |
| SCHEMBL19365792 | 0.86 | MEN1 (0.38) | DYRK1AGSK3BEGFRCYP11B1CYP11B2 | |
| SCHEMBL19365768 | 0.86 | EGFR (0.45) | DYRK1AGSK3BALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL19670463 | 0.86 | EGFR (0.45) | DYRK1AGSK3BALDH1A1SMN1; SMN2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |