Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 12/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365402 | 1.00 | PIK3C3 (0.42) | PIK3C3ATRNPC1RAB9ALMNA | |
| SCHEMBL19365766 | 0.89 | ATR (0.47) | ATRNPC1RAB9ALMNATSHR | |
| SCHEMBL19365765 | 0.89 | ATR (0.47) | ATRNPC1RAB9ALMNATSHR | |
| SCHEMBL19365399 | 0.88 | PRMT5 (0.40) | NPC1RAB9AGSK3BDYRK1A | |
| SCHEMBL19365398 | 0.88 | PRMT5 (0.40) | NPC1RAB9AGSK3BDYRK1A | |
| SCHEMBL19670325 | 0.87 | GSK3B (0.39) | GSK3BDYRK1A | |
| SCHEMBL19365582 | 0.87 | GSK3B (0.39) | GSK3BDYRK1A | |
| SCHEMBL19670317 | 0.86 | DYRK1A (0.42) | NPC1RAB9ALMNAGSK3BDYRK1A | |
| SCHEMBL19365296 | 0.86 | DYRK1A (0.42) | NPC1RAB9ALMNAGSK3BDYRK1A | |
| SCHEMBL17624238 | 0.86 | PIK3C3 (0.41) | PIK3C3ATRNPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |