Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 4/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.35 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670240 | 0.89 | PRMT5 (0.37) | HDAC2ATMTRPV1MAP4K4 | |
| SCHEMBL19365728 | 0.88 | HDAC2 (0.43) | HDAC2HDAC1HDAC3ABL1SLC6A9 | |
| SCHEMBL19669983 | 0.87 | HDAC1 (0.42) | HDAC2MAPTGSK3BHDAC1HDAC3 | |
| SCHEMBL19365429 | 0.85 | POLB (0.36) | HDAC2MAP4K4 | |
| SCHEMBL19365702 | 0.84 | SCN10A (0.34) | HDAC2MAPTSLC6A9ATMTRPV1 | |
| SCHEMBL19670470 | 0.84 | MAP4K1 (0.38) | ABL1 | |
| SCHEMBL19670603 | 0.83 | POLB (0.43) | TRPV1 | |
| SCHEMBL19669951 | 0.83 | MCHR1 (0.36) | HDAC2GSK3BABL1MAP4K4 | |
| SCHEMBL19365379 | 0.82 | HDAC2 (0.44) | HDAC2 | |
| SCHEMBL19365336 | 0.81 | ATR (0.37) | HDAC2MAPTGSK3BHDAC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |