Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365604 | 0.91 | HDAC1 (0.46) | HDAC1HDAC2HDAC3POLBATM | |
| SCHEMBL19670509 | 0.88 | HDAC1 (0.41) | HDAC1HDAC2HDAC3POLBATM | |
| SCHEMBL19365331 | 0.87 | HDAC2 (0.37) | HDAC1HDAC2HDAC3ATMABL1 | |
| SCHEMBL19365323 | 0.86 | GRM5 (0.41) | HDAC1HDAC2HDAC3 | |
| SCHEMBL19669952 | 0.86 | POLB (0.41) | POLBATMABL1MEN1MAPT | |
| SCHEMBL19365325 | 0.85 | FAAH (0.36) | HDAC1HDAC2HDAC3ATMHPGD | |
| SCHEMBL19365336 | 0.85 | ATR (0.37) | HDAC1HDAC2HDAC3MAPTGSK3B | |
| SCHEMBL19365310 | 0.84 | TSHR (0.45) | HDAC1HDAC2HDAC3POLBABL1 | |
| SCHEMBL19365485 | 0.84 | MCL1 (0.47) | HDAC1HDAC2POLBMAPTNAMPT | |
| SCHEMBL19365778 | 0.83 | HDAC3 (0.39) | HDAC1HDAC2HDAC3POLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |