Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 2/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 4/20 | 0.33 |
| ▸ | LYN | P07948 | 3/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | DEGS1 | O15121 | 2/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | LPL | P06858 | 1/20 | 0.31 |
| ▸ | LIPC | P11150 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706030 | 1.00 | SCD (0.37) | SCDITKSRCLYNBTK | |
| SCHEMBL19365385 | 0.89 | CNR2 (0.35) | BTKFGFR4VCPALDH1A1 | |
| SCHEMBL19703416 | 0.89 | CNR2 (0.35) | BTKFGFR4VCPALDH1A1 | |
| SCHEMBL17618391 | 0.88 | SCD (0.41) | SCDDEGS1MAP4K4ABL1 | |
| SCHEMBL19365358 | 0.87 | FAAH (0.35) | — | |
| SCHEMBL19706066 | 0.87 | FAAH (0.35) | — | |
| SCHEMBL19670259 | 0.87 | FAAH (0.35) | — | |
| SCHEMBL19670171 | 0.87 | PIM2 (0.32) | LPLLIPCLIPGALDH1A1ABL1 | |
| SCHEMBL17618376 | 0.86 | GRM5 (0.39) | SCD | |
| SCHEMBL17618499 | 0.86 | GRM5 (0.39) | SCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |