Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | NEK2 | P51955 | 1/20 | 0.32 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706066 | 1.00 | FAAH (0.35) | FAAHSIRT2DYRK1AGSK3BKARS1 | |
| SCHEMBL19365385 | 0.92 | CNR2 (0.35) | FAAHSIRT2DYRK1AGSK3BKMT2A | |
| SCHEMBL19703416 | 0.92 | CNR2 (0.35) | FAAHSIRT2DYRK1AGSK3BKMT2A | |
| SCHEMBL19365358 | 0.89 | FAAH (0.35) | FAAHGRM5PIM2PIM3 | |
| SCHEMBL19670387 | 0.89 | HTR2C (0.38) | FAAHPIM2PIM3 | |
| SCHEMBL19670254 | 0.87 | NEK2 (0.34) | DYRK1ANEK2 | |
| SCHEMBL19670391 | 0.87 | NEK2 (0.34) | DYRK1APIM2NEK2 | |
| SCHEMBL19706067 | 0.87 | NEK2 (0.34) | DYRK1APIM2NEK2 | |
| SCHEMBL19706030 | 0.87 | SCD (0.37) | — | |
| SCHEMBL19365346 | 0.87 | SCD (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |