Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.34 |
| ▸ | CLK2 | P49760 | 2/20 | 0.34 |
| ▸ | CLK3 | P49761 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 7/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | LPL | P06858 | 1/20 | 0.33 |
| ▸ | LIPC | P11150 | 1/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618718 | 0.88 | PRMT5 (0.36) | PIM2CLK2CLK3DYRK1ABTK | |
| SCHEMBL17618674 | 0.87 | PIM2 (0.43) | PIM2PIM3ABL1CYP3A4CYP2D6 | |
| SCHEMBL19365348 | 0.87 | PIM2 (0.34) | PIM2PIM3CLK2CLK3DYRK1A | |
| SCHEMBL17618636 | 0.87 | SCN10A (0.39) | CLK2CLK3DYRK1ABTKABL1 | |
| SCHEMBL17618740 | 0.86 | ABL1 (0.38) | CLK2CLK3DYRK1AABL1 | |
| SCHEMBL17618608 | 0.85 | SCN10A (0.38) | PIM2CLK2CLK3DYRK1ABTK | |
| SCHEMBL17618691 | 0.84 | ABL1 (0.38) | PIM2DYRK1AABL1 | |
| SCHEMBL19365550 | 0.84 | PIM2 (0.37) | PIM2PIM3 | |
| SCHEMBL19365639 | 0.84 | PIM2 (0.38) | PIM2PIM3DYRK1ABTK | |
| SCHEMBL16754551 | 0.83 | ROCK2 (0.38) | PIM2PIM3CLK2CLK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |