Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 5/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365285 | 0.90 | MTOR (0.35) | GSK3BIRAK4GRM5MAPTMTOR | |
| SCHEMBL19670184 | 0.90 | MDM2 (0.39) | MDM2CNR2GSK3BDYRK1AHCRTR2 | |
| SCHEMBL19364893 | 0.88 | CYP1A2 (0.39) | GSK3BDYRK1AIRAK4GRM5MTOR | |
| SCHEMBL19365613 | 0.87 | FAAH (0.40) | CNR2GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19365426 | 0.85 | GSK3B (0.41) | GSK3BDYRK1AGRM5PTGS1PTGS2 | |
| SCHEMBL19365658 | 0.84 | FGFR4 (0.40) | GSK3BDYRK1AHCRTR2IRAK4MAPT | |
| SCHEMBL17618761 | 0.84 | CNR2 (0.40) | MDM2CNR2GSK3BDYRK1AHCRTR2 | |
| SCHEMBL19365276 | 0.84 | WNT3A (0.41) | GSK3BDYRK1AGRM5PTGS1PTGS2 | |
| SCHEMBL19365317 | 0.84 | GSK3B (0.39) | CNR2GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19365370 | 0.83 | PTGS1 (0.41) | AVPR1AGRM5PTGS1PTGS2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |