Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | KARS1 | Q15046 | 2/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.35 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | GRM5 | P41594 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | CLK3 | P49761 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365456 | 1.00 | FGFR4 (0.39) | FGFR4KARS1SCDCSF1RMET | |
| SCHEMBL19670311 | 0.93 | FGFR4 (0.37) | FGFR4KARS1SCDCSF1RMET | |
| SCHEMBL19365483 | 0.89 | KARS1 (0.43) | FGFR4KARS1LRRK2DYRK1A | |
| SCHEMBL19365732 | 0.89 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL19365599 | 0.89 | KARS1 (0.40) | KARS1DYRK1A | |
| SCHEMBL19365330 | 0.87 | KARS1 (0.35) | KARS1LRRK2DYRK1A | |
| SCHEMBL19365789 | 0.87 | KARS1 (0.35) | KARS1LRRK2DYRK1A | |
| SCHEMBL19365587 | 0.87 | FGFR4 (0.39) | FGFR4CSF1RMETKDRNPY5R | |
| SCHEMBL19365490 | 0.86 | KARS1 (0.37) | KARS1LRRK2 | |
| SCHEMBL19706156 | 0.84 | FGFR4 (0.38) | FGFR4KARS1SCDCSF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |