Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | KLK1 | P06870 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.33 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | KIT | P10721 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365789 | 0.90 | KARS1 (0.35) | KARS1LRRK2KLKB1KLK1ABL1 | |
| SCHEMBL19365330 | 0.90 | KARS1 (0.35) | KARS1LRRK2KLKB1KLK1ABL1 | |
| SCHEMBL19365732 | 0.88 | KARS1 (0.40) | KARS1KDM4EPRKD1 | |
| SCHEMBL19365599 | 0.88 | KARS1 (0.40) | KARS1KDM4EPRKD1 | |
| SCHEMBL19365483 | 0.88 | KARS1 (0.43) | KARS1LRRK2PRKD1TP53BP1 | |
| SCHEMBL19365564 | 0.86 | FGFR4 (0.39) | KARS1LRRK2 | |
| SCHEMBL19365456 | 0.86 | FGFR4 (0.39) | KARS1LRRK2 | |
| SCHEMBL19361183 | 0.81 | KARS1 (0.35) | KARS1LRRK2KLKB1KLK1ABL1 | |
| SCHEMBL19670311 | 0.79 | FGFR4 (0.37) | KARS1LRRK2 | |
| SCHEMBL19670159 | 0.77 | KARS1 (0.40) | KARS1ABL1PRKD1TP53BP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |