Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 6/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.38 |
| ▸ | MAOA | P21397 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365318 | 0.90 | ALOX15 (0.46) | KDM1AKMOTRPV1MAOBMAOA | |
| SCHEMBL19365324 | 0.90 | MPL (0.44) | KDM1AKMOTRPV1MAOBMAOA | |
| SCHEMBL19365470 | 0.89 | KDM1A (0.40) | KDM1AKMOMAOBMAOAJAK2 | |
| SCHEMBL19365345 | 0.88 | KDM1A (0.39) | KDM1AKMOTRPV1MAOBMAOA | |
| SCHEMBL19365711 | 0.86 | KDM1A (0.42) | KDM1AKMOTRPM8TRPV1PHGDH | |
| SCHEMBL19365326 | 0.86 | KDM1A (0.41) | KDM1AKMOTRPV1MAOBMAOA | |
| SCHEMBL19365260 | 0.85 | KMO (0.39) | KDM1AKMOMAOBMAOAJAK2 | |
| SCHEMBL19365715 | 0.85 | KDM1A (0.42) | KDM1AMAOBMAOAJAK2MAPT | |
| SCHEMBL19365257 | 0.85 | PHGDH (0.46) | KDM1APHGDHMAOBMAOAJAK2 | |
| SCHEMBL19365332 | 0.84 | KDR (0.40) | KDM1AMAOBMAOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |