Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | UBE2M | P61081 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670419 | 0.95 | KMT2A (0.38) | TSHRKMT2ACA2CA9TRPV1 | |
| SCHEMBL20632966 | 0.88 | CA2 (0.39) | TSHRKMT2ACA2CA9TRPV1 | |
| SCHEMBL19862439 | 0.87 | KMT2A (0.41) | TSHRKMT2ACA2CA9TRPV1 | |
| SCHEMBL16250002 | 0.86 | KMT2A (0.37) | TSHRKMT2ACA2CA9TRPV1 | |
| SCHEMBL19361184 | 0.86 | ITGB1 (0.46) | CA2CA9 | |
| SCHEMBL16785514 | 0.86 | KMT2A (0.37) | TSHRKMT2ACA2CA9TRPV1 | |
| SCHEMBL17618652 | 0.86 | CA2 (0.31) | CA2CA9JAK2 | |
| SCHEMBL19365864 | 0.85 | KMT2A (0.39) | TSHRKMT2ACA2CA9HDAC6 | |
| SCHEMBL19346988 | 0.84 | CASP6 (0.41) | TSHRKMT2ACASP6HDAC1DRD2 | |
| SCHEMBL19346987 | 0.84 | CASP6 (0.41) | TSHRKMT2ACASP6HDAC1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |