Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.33 |
| ▸ | RORC | P51449 | 7/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.31 |
| ▸ | CKS1B | P61024 | 1/20 | 0.31 |
| ▸ | SKP1 | P63208 | 1/20 | 0.31 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.31 |
| ▸ | PTPRB | P23467 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670555 | 0.83 | RHOA (0.35) | RHOAGPR119RORCIRAK1CCR3 | |
| SCHEMBL19365673 | 0.81 | RHOA (0.39) | RHOAIDH2 | |
| SCHEMBL19706088 | 0.80 | RORC (0.34) | RORCCKS1BSKP1SKP2PTPRB | |
| SCHEMBL19670542 | 0.79 | RHOA (0.39) | RHOAIDH2 | |
| SCHEMBL17624671 | 0.79 | RHOA (0.38) | RHOAGPR119RORCIRAK1SYK | |
| SCHEMBL19365585 | 0.78 | RHOA (0.40) | RHOASYKCCR3IDH2 | |
| SCHEMBL19670126 | 0.78 | IRAK1 (0.34) | RORCIRAK1PTPRBSYKIDH2 | |
| SCHEMBL19365867 | 0.78 | RHOA (0.37) | RHOAGPR119RORCIRAK1SYK | |
| SCHEMBL17624583 | 0.78 | RHOA (0.37) | RHOAGPR119RORCIRAK1SYK | |
| SCHEMBL16785596 | 0.76 | RHOA (0.37) | RHOAGPR119RORCCKS1BSKP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |