Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | IDH2 | P48735 | 3/20 | 0.34 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | PHGDH | O43175 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365242 | 0.96 | MAPK14 (0.37) | RHOAMAPK14PTPN11MAPK13MAPK12 | |
| SCHEMBL19365673 | 0.86 | RHOA (0.39) | RHOAMAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL17624504 | 0.85 | RHOA (0.43) | RHOAIDH2PHGDHDGAT2 | |
| SCHEMBL19706172 | 0.82 | IDH2 (0.40) | IDH2 | |
| SCHEMBL16238636 | 0.81 | RHOA (0.40) | RHOAIDH2MTORSMG1MAP3K12 | |
| SCHEMBL19670200 | 0.80 | FAAH (0.36) | MAPK14IDH2PHGDH | |
| SCHEMBL19365701 | 0.79 | RHOA (0.35) | RHOAIDH2 | |
| SCHEMBL19706053 | 0.78 | IDH2 (0.39) | IDH2 | |
| SCHEMBL17624498 | 0.78 | RHOA (0.40) | RHOAIDH2KARS1MTORSMG1 | |
| SCHEMBL20733187 | 0.78 | IDH2 (0.41) | IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |