Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 4/20 | 0.39 |
| ▸ | VCP | P55072 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | UBE2M | P61081 | 3/20 | 0.37 |
| ▸ | PLG | P00747 | 1/20 | 0.37 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | PLAT | P00750 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365306 | 0.98 | POLB (0.44) | POLBRAB9AMCHR1HDAC1KIF11 | |
| SCHEMBL19365784 | 0.92 | POLB (0.47) | POLBRAB9AMCHR1DCUN1D1UBE2M | |
| SCHEMBL19365636 | 0.88 | POLB (0.46) | POLBRAB9AMCHR1KIF11CA2 | |
| SCHEMBL19365571 | 0.86 | MCHR1 (0.42) | POLBRAB9AMCHR1KIF11CA2 | |
| SCHEMBL19706137 | 0.86 | MCHR1 (0.43) | POLBRAB9AMCHR1KIF11CA2 | |
| SCHEMBL19670560 | 0.85 | POLB (0.47) | POLBRAB9AMCHR1CA2CA9 | |
| SCHEMBL19365519 | 0.84 | POLB (0.46) | POLBRAB9AMCHR1HDAC1KIF11 | |
| SCHEMBL19706296 | 0.83 | POLB (0.39) | POLBRAB9AMCHR1HDAC1CA2 | |
| SCHEMBL19670603 | 0.83 | POLB (0.43) | POLBRAB9AMCHR1KIF11CA2 | |
| SCHEMBL19706120 | 0.83 | POLB (0.45) | POLBRAB9AMCHR1KIF11CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |