Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | FPR1 | P21462 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19706137 | 0.99 | MCHR1 (0.43) | MCHR1CA2CA9FPR1FPR2 | |
| SCHEMBL19365306 | 0.87 | POLB (0.44) | MCHR1CA2CA9RAB9APOLB | |
| SCHEMBL19365636 | 0.86 | POLB (0.46) | MCHR1CA2CA9RAB9APOLB | |
| SCHEMBL19365722 | 0.86 | POLB (0.41) | MCHR1CA2CA9RAB9APOLB | |
| SCHEMBL19365519 | 0.83 | POLB (0.46) | MCHR1RAB9APOLBKIF11BRAF | |
| SCHEMBL19670560 | 0.82 | POLB (0.47) | MCHR1CA2CA9RAB9APOLB | |
| SCHEMBL19670603 | 0.82 | POLB (0.43) | MCHR1CA2CA9RAB9APOLB | |
| SCHEMBL19365784 | 0.82 | POLB (0.47) | MCHR1RAB9APOLB | |
| SCHEMBL19365835 | 0.81 | CNR2 (0.53) | — | |
| SCHEMBL19670601 | 0.81 | POLB (0.41) | MCHR1CA2CA9RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |