Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 5/20 | 0.39 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | ATR | Q13535 | 2/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.33 |
| ▸ | STK3 | Q13188 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365839 | 0.90 | CNR2 (0.51) | GRM5CNR2ATRKMOALDH1A1 | |
| SCHEMBL19365679 | 0.88 | POLB (0.41) | GRM5CNR2ATRKMOALDH1A1 | |
| SCHEMBL19703381 | 0.88 | GRM5 (0.42) | MPLGRM5CNR2ATRKMO | |
| SCHEMBL19365769 | 0.88 | MPL (0.43) | MPLATRKMO | |
| SCHEMBL19365796 | 0.86 | CNR2 (0.38) | CNR2ATRKMOALDH1A1FAAH | |
| SCHEMBL19365601 | 0.85 | CNR1 (0.36) | GRM5CNR2MAP4K4FAAHSTK4 | |
| SCHEMBL19365680 | 0.84 | TSHR (0.44) | CNR2ATRALDH1A1ABL1 | |
| SCHEMBL19365671 | 0.82 | BRAF (0.38) | GRM5CNR2 | |
| SCHEMBL19365584 | 0.81 | BRAF (0.36) | GRM5CNR2ATR | |
| SCHEMBL19365578 | 0.81 | BRAF (0.36) | GRM5CNR2ATRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |