Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 3/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.34 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.34 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.34 |
| ▸ | GRM5 | P41594 | 2/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365547 | 0.90 | ATR (0.35) | BRAFATRCNR2ABL1KDR | |
| SCHEMBL19365680 | 0.88 | TSHR (0.44) | ATRCNR2ABL1 | |
| SCHEMBL19365509 | 0.88 | PHGDH (0.38) | CNR2SCN10AFYNMCHR1 | |
| SCHEMBL19365679 | 0.83 | POLB (0.41) | BRAFATRCNR2GRM5 | |
| SCHEMBL19365668 | 0.83 | BRAF (0.43) | BRAFATRCNR2FYN | |
| SCHEMBL19365772 | 0.82 | ABL1 (0.38) | CNR2ABL1PTGER4 | |
| SCHEMBL19365852 | 0.81 | MPL (0.41) | ATRCNR2ABL1GRM5 | |
| SCHEMBL19365839 | 0.81 | CNR2 (0.51) | ATRCNR2GRM5 | |
| SCHEMBL19365584 | 0.80 | BRAF (0.36) | BRAFATRCNR2KDRGRM5 | |
| SCHEMBL19365601 | 0.80 | CNR1 (0.36) | CNR2ABL1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |