Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365839 | 0.90 | CNR2 (0.51) | GRM5CNR2SIRT2ATRKMO | |
| SCHEMBL19365852 | 0.88 | MPL (0.41) | GRM5CNR2ATRKMOALDH1A1 | |
| SCHEMBL19670563 | 0.88 | ALOX15 (0.44) | SIRT2HDAC3HDAC1HDAC2KMO | |
| SCHEMBL19365680 | 0.87 | TSHR (0.44) | POLBKMT2AMEN1CNR2ATR | |
| SCHEMBL19365796 | 0.86 | CNR2 (0.38) | CNR2SIRT2ATRRAB9AKMO | |
| SCHEMBL19365671 | 0.85 | BRAF (0.38) | GRM5CNR2BRAF | |
| SCHEMBL19365547 | 0.83 | ATR (0.35) | GRM5CNR2ATRBRAFKDM1A | |
| SCHEMBL19365578 | 0.83 | BRAF (0.36) | GRM5CNR2ATRBRAF | |
| SCHEMBL19365584 | 0.83 | BRAF (0.36) | GRM5CNR2ATRBRAF | |
| SCHEMBL19365601 | 0.82 | CNR1 (0.36) | KMT2AMEN1GRM5CNR2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |