Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 10/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 4/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15768673 | 0.79 | HDAC4 (1.00) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL15768960 | 0.77 | HDAC4 (0.68) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL16602145 | 0.77 | NPC1 (0.54) | HDAC4RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL436106 | 0.74 | NPC1 (0.65) | HDAC4RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL16727393 | 0.73 | RAB9A (0.55) | HDAC4RAB9ANPC1SMN1; SMN2ADORA1 | |
| SCHEMBL29686802 | 0.72 | MAP4K4 (0.54) | HDAC4RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL17055377 | 0.70 | NPC1 (0.67) | HDAC4RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL10091200 | 0.70 | NPC1 (0.67) | HDAC4RAB9ANPC1NFKB1NFKB2 | |
| SCHEMBL15768963 | 0.70 | HDAC4 (0.57) | HDAC4HDAC3HDAC7HDAC8HDAC6 | |
| SCHEMBL15768961 | 0.70 | HDAC4 (0.57) | HDAC4HDAC3HDAC7HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765054-B2 | Histone deacetylase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2017-09-19 | — | — | US | disclosed |