Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | TDP2 | O95551 | 1/20 | 0.49 |
| ▸ | NSD2 | O96028 | 1/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.49 |
| ▸ | GALK1 | P51570 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.49 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1579169 | 0.85 | PIK3CA (0.58) | PIK3CAPIK3CBKMT2AAURKARAB9A | |
| SCHEMBL17607788 | 0.85 | PIK3CA (0.58) | PIK3CAPIK3CBKMT2AAURKARAB9A | |
| SCHEMBL13336854 | 0.84 | KMT2A (0.57) | PIK3CAPIK3CBKMT2ACRHBPCRHR2 | |
| SCHEMBL3276269 | 0.84 | PIK3CA (0.58) | PIK3CAPIK3CBKMT2ACRHBPCRHR2 | |
| SCHEMBL23949228 | 0.82 | KMT2A (0.48) | PIK3CAPIK3CBKMT2ACRHBPCRHR2 | |
| SCHEMBL30353350 | 0.82 | KMT2A (0.48) | PIK3CAPIK3CBKMT2ACRHBPCRHR2 | |
| SCHEMBL31320165 | 0.81 | PTGER4 (0.44) | PIK3CAPIK3CBKMT2ARAB9AMEN1 | |
| SCHEMBL31704530 | 0.78 | PIK3CA (0.74) | PIK3CAPIK3CBRAB9AALDH1A1HPGD | |
| SCHEMBL1516978 | 0.78 | PIK3CA (0.74) | PIK3CAPIK3CBRAB9AALDH1A1HPGD | |
| SCHEMBL23259072 | 0.77 | PIK3CA (0.54) | PIK3CAPIK3CBKMT2AAURKARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267656-A1 | PYRAZOLYL-SUBSTITUTED PYRIDONE COMPOUNDS AS SERINE PROTEASE INHIBITORS | SERPINE1, PRSS1, SPINT2 | PIK3CA 927/4885PIK3CB 1343/4885KMT2A 2496/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.