Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20353021 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL18356836 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL23511774 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL20353019 | 1.00 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL21757546 | 0.96 | ALDH1A1 (0.59) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL20353085 | 0.93 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL20337462 | 0.89 | ALDH1A1 (0.52) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL17743069 | 0.89 | ALDH1A1 (0.52) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL19579144 | 0.88 | GAA (0.52) | ALDH1A1KDM4EPOLBHPGDRAB9A | |
| SCHEMBL22754745 | 0.88 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215509-B1 | SUBSTITUTED PYRROLO[1,2-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC (US) | 2020-02-26 | — | — | EP | disclosed |
| WO-2017192841-A1 | METHODS OF TREATMENT AND COMBINATION THERAPIES USING GCASE ACTIVATOR HETEROBICYCLIC AND RELATED COMPOUNDS | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-11-09 | — | — | WO | disclosed |
| WO-2017161137-A1 | METHODS AND COMPOSITIONS FOR TREATING A NEURODEGENERATIVE DISORDER IN A SPHINGOTYPED SUBJECT | LYSOSOMAL THERAPEUTICS INC. (US) | 2017-09-21 | — | — | WO | disclosed |