Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18356836 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL23511774 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL20353021 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL19368286 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL20353019 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL20353085 | 0.90 | ALDH1A1 (0.57) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL17743056 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL20337386 | 0.90 | ALDH1A1 (0.49) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL22754745 | 0.89 | ALDH1A1 (0.50) | ALDH1A1KDM4EPOLBRAB9AHPGD | |
| SCHEMBL18357161 | 0.89 | POLR1A (0.54) | ALDH1A1KDM4EPOLBRAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3215509-B1 | SUBSTITUTED PYRROLO[1,2-A]PYRIMIDINES AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS | LYSOSOMAL THERAPEUTICS INC (US) | 2020-02-26 | — | — | EP | disclosed |