Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10088096 | 0.78 | RECQL (0.42) | SMN1; SMN2RECQLMEN1KMT2A | |
| SCHEMBL11598889 | 0.78 | RECQL (0.42) | SMN1; SMN2RECQLMEN1KMT2A | |
| SCHEMBL5627160 | 0.74 | ALDH1A1 (0.46) | SMN1; SMN2RECQLMEN1KMT2A | |
| SCHEMBL10941017 | 0.72 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL2011908 | 0.72 | ALDH1A1 (0.49) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL25515898 | 0.72 | HRH3 (0.35) | MEN1KMT2A | |
| SCHEMBL20399152 | 0.71 | KMT2A (0.47) | SMN1; SMN2RECQLMEN1KMT2A | |
| SCHEMBL20399168 | 0.71 | KMT2A (0.47) | SMN1; SMN2RECQLMEN1KMT2A | |
| SCHEMBL20868537 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2RECQLKMT2A | |
| SCHEMBL20868364 | 0.69 | ALDH1A1 (0.46) | SMN1; SMN2RECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017161028-A1 | SUBSTITUTED INHIBITORS OF MENIN-MLL AND METHODS OF USE | KURA ONCOLOGY, INC. (US) | 2017-09-21 | — | — | WO | disclosed |