Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR8 | P51685 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | RHEB | Q15382 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15367385 | 0.78 | CCR8 (0.59) | CCR8KMT2APARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL11205036 | 0.75 | CCR8 (0.67) | CCR8KMT2APARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL11699295 | 0.71 | CCR8 (0.60) | CCR8KMT2ASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL19683290 | 0.71 | PARP1 (0.44) | CCR8KMT2APARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL22492390 | 0.70 | CCR8 (0.48) | CCR8KMT2ASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL11696777 | 0.69 | CCR8 (0.58) | CCR8KMT2ASMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL19318056 | 0.69 | CCR8 (1.00) | CCR8KMT2APARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL30774416 | 0.69 | CCR8 (1.00) | CCR8KMT2APARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL20657858 | 0.69 | ALDH1A1 (0.44) | CCR8KMT2APARP1SMN1; SMN2HSD17B10 | |
| SCHEMBL21050882 | 0.69 | CCR8 (0.47) | CCR8KMT2ASMN1; SMN2HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017160670-A1 | M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS AND METHODS OF USE THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-09-21 | — | — | WO | disclosed |