Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 6/20 | 0.48 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.48 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 12/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21499695 | 0.92 | TRPC5 (0.59) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505396 | 0.92 | TRPC4 (0.41) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19375680 | 0.89 | TRPC4 (0.46) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL20432442 | 0.85 | TRPC5 (0.48) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL21499677 | 0.85 | TRPC5 (0.51) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505516 | 0.85 | TRPC5 (0.47) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL18834916 | 0.84 | TRPC4 (0.45) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL21499669 | 0.84 | TRPC5 (0.49) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19375611 | 0.84 | TRPC4 (0.41) | TRPC5TRPC4TRPC1P2RX3KCNH2 | |
| SCHEMBL19505394 | 0.84 | TRPC5 (0.48) | TRPC5TRPC4TRPC1P2RX3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |