Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 7/20 | 0.38 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 6/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19375680 | 0.91 | TRPC4 (0.46) | TRPC4TRPC5KCNH2PDE5ATRPC1 | |
| SCHEMBL20432442 | 0.86 | TRPC5 (0.48) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL19505394 | 0.86 | TRPC5 (0.48) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL21499684 | 0.86 | P2RX3 (0.44) | TRPC4TRPC5KCNH2PDE5AP2RX3 | |
| SCHEMBL19505516 | 0.85 | TRPC5 (0.47) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL18834945 | 0.85 | TRPC4 (0.39) | TRPC4TRPC5KCNH2LMNAHTT | |
| SCHEMBL18834254 | 0.84 | TRPC4 (0.40) | TRPC4TRPC5KCNH2LMNAHTT | |
| SCHEMBL19375592 | 0.84 | TRPC5 (0.48) | TRPC4TRPC5KCNH2TRPC1P2RX3 | |
| SCHEMBL19505396 | 0.84 | TRPC4 (0.41) | TRPC4TRPC5KCNH2PDE5ATRPC1 | |
| SCHEMBL21316302 | 0.84 | TRPC4 (0.41) | TRPC4TRPC5KCNH2TRPC1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B9 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2017-09-20 | — | — | EP | disclosed |