Succinic Acid

Succinic Acid

SCHEMBL193756

O=C(O)CC(O)C(=O)OCCCCO.O=C(O)CCC(=O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4

The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.42
FFAR1 O14842 1/20 0.42
FFAR4 Q5NUL3 1/20 0.42
CAMK2A Q9UQM7 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
FNTA P49354 1/20 0.34
FNTB P49356 1/20 0.34
ACHE P22303 6/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28245447 0.94 SMN1; SMN2 (0.43) GPR84FFAR1FFAR4CAMK2ASMN1; SMN2
SCHEMBL11669561 0.93 SMN1; SMN2 (0.41) GPR84FFAR1FFAR4SMN1; SMN2FNTA
SCHEMBL5710082 0.89 SMN1; SMN2 (0.44) GPR84FFAR1FFAR4CAMK2ASMN1; SMN2
SCHEMBL8985139 0.87 SMN1; SMN2 (0.50) SMN1; SMN2
SCHEMBL5586416 0.81 SMN1; SMN2 (0.48) SMN1; SMN2ACHE
SCHEMBL16413119 0.79 NAAA (0.39) ACHE
Malic Acid SCHEMBL193758 0.79 SMN1; SMN2 (0.65) GPR84FFAR1FFAR4CAMK2ASMN1; SMN2
SCHEMBL22772391 0.79 NPC1 (0.39) ALDH1A1
SCHEMBL11416022 0.78 SMN1; SMN2 (0.41) SMN1; SMN2ALDH1A1
SCHEMBL11435907 0.78 SMN1; SMN2 (0.41) SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3897452-B1 RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS TEPHA INC (US) 2024-07-03 EP claimed
US-11896734-B2 Surgical mesh implants containing poly(butylene succinate) and copolymers thereof TEPHA, INC. (US) 2024-02-13 US claimed
US-11878087-B2 Oriented implants containing poly(butylene succinate) and copolymer, and methods of use thereof TEPHA, INC. (US) 2024-01-23 US claimed
US-11786632-B2 Hernia repair, breast reconstruction and sling devices containing poly(butylene succinate) and copolymers thereof TEPHA, INC. (US) 2023-10-17 US claimed
US-20230201610-A1 RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS TEPHA, INC. (US) 2023-06-29 US claimed
US-11612754-B2 Resorbable nonwoven pouches for medical device implants TEPHA, INC. (US) 2023-03-28 US claimed
EP-4021518-A1 MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF Tepha, Inc. (US) 2022-07-06 EP claimed
US-20220202988-A1 YARNS AND FIBERS OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF, AND METHODS OF USE THEREOF TEPHA, INC. (US) 2022-06-30 US claimed
CN-114630931-A Medical devices comprising poly (butylene succinate) and copolymers thereof 特法公司 2022-06-14 CN claimed
WO-2021042044-A1 MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF TEPHA, INC. (US) 2021-03-04 WO claimed
EP-3758764-A1 MEDICAL DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF Tepha, Inc. (US) 2021-01-06 EP claimed
US-20200197712-A1 RESORBABLE NONWOVEN POUCHES FOR MEDICAL DEVICE IMPLANTS TEPHA, INC. 2020-06-25 US claimed
US-20190269817-A1 SURGIAL MESH IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF TEPHA, INC. 2019-09-05 US claimed
US-20190269822-A1 HERNIA REPAIR, BREAST RECONSTRUCTION AND SLING DEVICES CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF TEPHA, INC. 2019-09-05 US claimed
US-20190269815-A1 YARNS AND FIBERS OF POLY(BUTYLENE SUCCINATE) AND COPOLYMERS THEREOF, AND METHODS OF USE THEROF TEPHA, INC. 2019-09-05 US claimed
US-20190269816-A1 ORIENTED IMPLANTS CONTAINING POLY(BUTYLENE SUCCINATE) AND COPOLYMER, AND METHODS OF USE THEREOF TEPHA, INC. 2019-09-05 US claimed
US-20240238077-A1 NIPPLE RECONSTRUCTION IMPLANT TEPHA, INC. (US) 2024-07-18 US disclosed
EP-3925997-B1 BIOMASS-RESOURCE-DERIVED POLYESTER AND PRODUCTION PROCESS THEREOF MITSUBISHI CHEM CORP (JP) 2024-07-17 EP disclosed
US-20090171037-A1 a dicarboxylic acid and/or a diol derived from biomass resources; capable of suppressing hydrolysis; environmentally friendly; eco-friendly MITSUBISHI CHEMICAL CORPORATION (JP) 2009-07-02 US disclosed
EP-1882712-A1 POLYESTER DERIVED FROM BIOMASS RESOURCES AND METHOD FOR PRODUCTION THEREOF Mitsubishi Chemical Corporation (JP) 2008-01-30 EP disclosed