Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 7/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1881949 | 0.84 | POLB (0.42) | POLQPOLBMGLLKDM4EGPR6 | |
| SCHEMBL2589049 | 0.84 | POLQ (0.39) | POLQMGLLGPR6MAP3K5 | |
| SCHEMBL30082715 | 0.84 | POLB (0.42) | POLQPOLBMGLLKDM4EGPR6 | |
| SCHEMBL1891278 | 0.83 | OPRK1 (0.46) | POLQMGLLKDM4EGPR6MAP3K5 | |
| SCHEMBL1887386 | 0.83 | GPR6 (0.40) | SQORPOLQMGLLGPR6MAP3K5 | |
| SCHEMBL29499589 | 0.82 | MKNK1 (0.42) | NNMTMKNK1MKNK2 | |
| SCHEMBL29499567 | 0.82 | MKNK1 (0.42) | NNMTMKNK1MKNK2 | |
| SCHEMBL24363781 | 0.81 | NNMT (0.47) | NNMTROCK2ROCK1SIRT6MKNK1 | |
| SCHEMBL31327199 | 0.81 | NNMT (0.50) | NNMTROCK2ROCK1SIRT6MKNK1 | |
| SCHEMBL8125788 | 0.79 | NNMT (0.46) | NNMTROCK2ROCK1CSF1RSIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331507-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | Astellas Pharma Inc. (JP) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010032875-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2010-03-25 | — | — | WO | disclosed |