Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | NPY2R | P49146 | 1/20 | 0.38 |
| ▸ | NPY4R | P50391 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19376109 | 0.88 | HRH1 (0.44) | ALDH1A1THRBHRH1SLC6A2SLC6A3 | |
| SCHEMBL20995905 | 0.85 | ALDH1A1 (0.50) | ALDH1A1THRBHRH1SLC6A2SLC6A3 | |
| SCHEMBL19381819 | 0.81 | MCHR1 (0.39) | MCHR1SLC6A2SLC6A3CARM1PRMT1 | |
| SCHEMBL29428932 | 0.81 | ALDH1A1 (0.54) | ALDH1A1THRBHRH1SLC6A2SLC6A3 | |
| SCHEMBL11457750 | 0.79 | HRH1 (0.46) | ALDH1A1THRBHRH1SLC6A2SLC6A3 | |
| SCHEMBL19382129 | 0.79 | CHRNB2 (0.49) | LMNA | |
| SCHEMBL11458402 | 0.78 | ATM (0.43) | HRH1SLC6A2SLC6A3CTSVCTSL | |
| SCHEMBL19381837 | 0.78 | ALDH1A1 (0.45) | ALDH1A1THRBHRH1SLC6A2SLC6A3 | |
| SCHEMBL20713128 | 0.77 | NPY1R (0.42) | MCHR1SLC6A2SLC6A3CARM1PRMT1 | |
| SCHEMBL15629805 | 0.77 | ALDH1A1 (0.45) | ALDH1A1THRBMCHR1SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233858-B1 | ERK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-30 | — | — | EP | disclosed |
| US-20170266167-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170266167-A1 | ERK INHIBITORS | MAPK1, MAPK3, MAPK6 | ALDH1A1 670/4885THRB 1756/4885HRH1 1861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.