Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 10/20 | 0.67 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.60 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.56 |
| ▸ | KDM5A | P29375 | 3/20 | 0.50 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.49 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24244174 | 0.89 | PHF8 (0.67) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL24244193 | 0.86 | PHF8 (0.61) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL17686561 | 0.83 | PHF8 (0.59) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL17604596 | 0.82 | PHF8 (0.71) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL17693141 | 0.80 | KDM4C (0.68) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL19383011 | 0.78 | KDM4C (0.63) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL19383405 | 0.78 | PHF8 (0.66) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL24244253 | 0.78 | PHF8 (0.64) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL17604637 | 0.78 | PHF8 (0.71) | PHF8KDM4CKDM2BKDM5AKDM5B | |
| SCHEMBL17686547 | 0.76 | PHF8 (0.61) | PHF8KDM4CKDM2BKDM5AKDM5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3436445-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2023-09-06 | — | — | EP | disclosed |
| EP-3193881-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2022-02-09 | — | — | EP | disclosed |
| WO-2017161033-A1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2017-09-21 | — | — | WO | disclosed |