Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHF8 | Q9UPP1 | 10/20 | 0.64 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.63 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.53 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 4/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.47 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604520 | 0.85 | PHF8 (0.62) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL16033817 | 0.83 | PHF8 (0.60) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL17621748 | 0.83 | PHF8 (0.60) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL17604572 | 0.83 | PHF8 (0.60) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL17693141 | 0.81 | KDM4C (0.68) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL17604562 | 0.81 | PHF8 (0.60) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL17604566 | 0.79 | KDM4C (0.70) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL24244164 | 0.79 | PHF8 (0.55) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL16033516 | 0.78 | KDM4C (1.00) | PHF8KDM4CKDM2BKDM2AKDM5A | |
| SCHEMBL20979031 | 0.78 | PHF8 (0.56) | PHF8KDM4CKDM2BKDM2AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3193881-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2022-02-09 | — | — | EP | disclosed |