Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15308297 | 0.94 | L3MBTL1 (0.67) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL15308225 | 0.92 | L3MBTL1 (0.69) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL22912145 | 0.87 | MEN1 (0.77) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL24776412 | 0.87 | ABCG2 (0.53) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL30030272 | 0.87 | ABCG2 (0.53) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL23383792 | 0.87 | ABCG2 (0.58) | KMT2AMEN1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL15308290 | 0.86 | L3MBTL1 (0.65) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL15458641 | 0.86 | MEN1 (0.80) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL19383481 | 0.86 | MEN1 (0.80) | L3MBTL1KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL15458659 | 0.86 | MEN1 (0.80) | L3MBTL1KMT2AMEN1HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190106391-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2019-04-11 | — | — | US | disclosed |
| WO-2017157983-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | MERCK PATENT GMBH (DE) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106391-A1 | COMPOUNDS WITH SPIROBIFLUORENE-STRUCTURES | TEC, NUDT1, DPYD | L3MBTL1 4788/4885KMT2A 3153/4885MEN1 1683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.