Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 4/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19384330 | 0.78 | CNR1 (0.47) | CNR1MAPTKDM4EL3MBTL1CA2 | |
| SCHEMBL19384363 | 0.76 | GHSR (0.53) | CNR1MAPTKDM4EL3MBTL1CA2 | |
| SCHEMBL19377062 | 0.76 | MMP2 (0.45) | MAPTCA2MMP2CA1LMNA | |
| SCHEMBL19377063 | 0.76 | MMP2 (0.45) | MAPTCA2MMP2CA1LMNA | |
| SCHEMBL19384365 | 0.76 | GAA (0.55) | CNR1KDM4EL3MBTL1CA2CA1 | |
| SCHEMBL19384347 | 0.75 | GHSR (0.59) | — | |
| SCHEMBL19384362 | 0.74 | CNR1 (0.41) | CNR1MAPTKDM4EL3MBTL1CA2 | |
| SCHEMBL19377021 | 0.72 | MMP2 (0.42) | MAPTCA2MMP2CA1LMNA | |
| SCHEMBL19377196 | 0.70 | MEN1 (0.41) | MAPTMMP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22834258 | 0.70 | CNR1 (1.00) | CNR1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3390355-A1 | BENZENESULFONYL-ASYMMETRIC UREAS AND MEDICAL USES THEREOF | Helsinn Healthcare S.A. (CH) | 2018-10-24 | — | — | EP | disclosed |
| WO-2017162390-A1 | BENZENESULFONYL-ASYMMETRIC UREAS AND MEDICAL USES THEREOF | HELSINN HEALTHCARE SA (CH) | 2017-09-28 | — | — | WO | disclosed |