Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.83 |
| ▸ | MAPT | P10636 | 4/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.83 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.83 |
| ▸ | HPGD | P15428 | 2/20 | 0.83 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.83 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.74 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.68 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.68 |
| ▸ | RELA | Q04206 | 3/20 | 0.68 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1938672 | 1.00 | MEN1 (0.83) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL25208499 | 0.94 | MEN1 (0.78) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL25208498 | 0.94 | MEN1 (0.78) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL25202026 | 0.92 | ABCG2 (0.83) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL31384903 | 0.92 | ABCG2 (0.83) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL5084292 | 0.91 | CYP3A4 (1.00) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL30383925 | 0.91 | CYP3A4 (1.00) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL5084287 | 0.91 | CYP3A4 (1.00) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL31235473 | 0.89 | MAPT (0.83) | MEN1KMT2AMAPTTDP1KDM4E | |
| SCHEMBL29056496 | 0.89 | MAPT (0.83) | MEN1KMT2AMAPTTDP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9061984-B2 | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061984-B2 | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9061984-B2 | Compounds related to chalcones and benzothienopyrimidines, their synthesis, and uses to treat diseases | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | THE JOHNS HOPKINS UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | THE JOHNS HOPKINS UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | THE JOHNS HOPKINS UNIVERSITY | 2011-08-04 | — | — | US | disclosed |
| EP-2330906-A1 | COMPOUNDS, THEIR SYNTHESES, AND THEIR USES | University Of Louisville Research Foundation, Inc. (US) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010019861-A1 | COMPOUNDS, THEIR SYNTHESES, AND THEIR USES | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
| WO-2010019861-A1 | COMPOUNDS, THEIR SYNTHESES, AND THEIR USES | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110190325-A1 | COMPOUNDS, THEIR SYNTHESES, AND THIER USES | TERT, TYMS, NISCH | MEN1 37/4885KMT2A 1587/4885MAPT 2194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.