Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 11/20 | 0.41 |
| ▸ | BCL3 | P20749 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EED | O75530 | 2/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19390858 | 0.92 | EZH2 (0.37) | EZH2BCL3KDM4ECASP1CASP7 | |
| SCHEMBL19391004 | 0.85 | EZH2 (0.41) | EZH2GAACASP1CASP7EED | |
| SCHEMBL19390687 | 0.85 | KDM4E (0.43) | EZH2BCL3KDM4EALDH1A1GAA | |
| SCHEMBL19390670 | 0.81 | EZH2 (0.42) | EZH2CASP1CASP7EEDRBBP4 | |
| SCHEMBL19391186 | 0.78 | EZH2 (0.45) | EZH2KDM4EALDH1A1HPGDCASP1 | |
| SCHEMBL19390962 | 0.78 | EZH2 (0.37) | EZH2BCL3KDM4EMAPTNPSR1 | |
| SCHEMBL19390927 | 0.76 | EZH2 (0.37) | EZH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17792540 | 0.75 | MTNR1B (0.36) | EZH2ALDH1A1TSHRKCNH2 | |
| SCHEMBL19390952 | 0.75 | ALOX5 (0.41) | EZH2KDM4EALDH1A1HPGDCASP1 | |
| SCHEMBL19391013 | 0.74 | EZH2 (0.41) | EZH2CASP1CASP7EEDRBBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022184-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |