Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.49 |
| ▸ | EED | O75530 | 2/20 | 0.45 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.45 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.45 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19391112 | 0.90 | EZH2 (0.48) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390924 | 0.88 | EZH2 (0.48) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390994 | 0.88 | EED (0.46) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391032 | 0.87 | EED (0.47) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19391115 | 0.86 | EZH2 (0.45) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390903 | 0.85 | EZH2 (0.52) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390952 | 0.83 | ALOX5 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390862 | 0.83 | EZH2 (0.48) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19390930 | 0.80 | EZH2 (0.51) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL20749753 | 0.80 | EZH2 (0.58) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3022184-B1 | SUBSTITUTED BENZENE COMPOUNDS | EPIZYME INC (US) | 2017-09-27 | — | — | EP | disclosed |