Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAT2 | Q10469 | 1/20 | 0.64 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | DGAT2 | Q96PD7 | 8/20 | 0.43 |
| ▸ | AOC1 | P19801 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15345687 | 0.80 | DPP4 (0.59) | MGAT2DPP4CYP2A6LOXL2 | |
| SCHEMBL17571771 | 0.79 | MGAT2 (1.00) | MGAT2DGAT2 | |
| SCHEMBL13212635 | 0.79 | DPP4 (0.59) | MGAT2TNFDPP4CYP1A2CYP2E1 | |
| SCHEMBL7014746 | 0.79 | DPP4 (0.59) | MGAT2TNFDPP4CYP1A2CYP2E1 | |
| SCHEMBL8232790 | 0.77 | TNF (0.56) | MGAT2TNFCYP1A2CYP2E1CYP3A4 | |
| SCHEMBL17558217 | 0.76 | MGAT2 (0.72) | MGAT2DGAT2 | |
| SCHEMBL17571196 | 0.75 | TNF (0.58) | MGAT2TNFCYP1A2 | |
| SCHEMBL19397234 | 0.74 | TNF (0.56) | MGAT2TNFCYP1A2CYP2A6DGAT2 | |
| SCHEMBL20608926 | 0.74 | EP300 (0.59) | MGAT2AOC1AOC3HTR6LOXL2 | |
| SCHEMBL1102708 | 0.74 | TNF (0.56) | MGAT2TNFCYP1A2HTR6PRKCZ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10568876-B2 | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2020-02-25 | — | — | US | disclosed |
| EP-3188731-B1 | ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME (US) | 2019-04-03 | — | — | EP | disclosed |
| US-9877957-B2 | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2018-01-30 | — | — | US | disclosed |
| US-9877957-B2 | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARP & DOHME CORP. (US) | 2018-01-30 | — | — | US | disclosed |
| US-9828369-B2 | Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARPE & DOHME CORP. (US) | 2017-11-28 | — | — | US | disclosed |
| US-9828369-B2 | Isoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | MERCK SHARPE & DOHME CORP. (US) | 2017-11-28 | — | — | US | disclosed |
| US-20170275274-A1 | ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273965-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273966-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273965-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
| US-20170273966-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | MERCK SHARP & DOHME CORP. (US) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170273965-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | MGAT2 27/4885TNF 2878/4885DPP4 305/4885 |
| US-20170273966-A1 | TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | MGAT2 33/4885TNF 3106/4885DPP4 371/4885 |
| US-10568876-B2 | Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2 | DGAT2, DGAT1, MOGAT2 | MGAT2 27/4885TNF 2878/4885DPP4 305/4885 |
| US-20170275274-A1 | ISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 | DGAT2, DGAT1, MOGAT2 | MGAT2 24/4885TNF 3399/4885DPP4 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.