Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | ACACA | Q13085 | 5/20 | 0.40 |
| ▸ | ACACB | O00763 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3229055 | 0.83 | TSHR (0.54) | ALDH1A1CYP2D6CYP3A4CYP2C19TSHR | |
| SCHEMBL10111316 | 0.82 | TMEM97 (0.47) | ALDH1A1CYP2D6CYP3A4TSHRHPGD | |
| SCHEMBL16430910 | 0.79 | ACACA (0.48) | ALDH1A1CYP2D6CYP3A4TSHRHPGD | |
| SCHEMBL30327875 | 0.78 | AR (0.45) | ALDH1A1CYP2D6CYP3A4CYP2C19TSHR | |
| SCHEMBL17723673 | 0.78 | CYP17A1 (0.40) | ALDH1A1CYP2D6CYP3A4CYP2C19TSHR | |
| SCHEMBL16438716 | 0.77 | KCNJ1 (0.46) | ALDH1A1CYP2D6CYP3A4TSHRHPGD | |
| Hydrochloric Acid SCHEMBL30328059 | 0.77 | AR (0.44) | ALDH1A1CYP2D6CYP3A4CYP2C19TSHR | |
| Hydrochloric Acid SCHEMBL30327714 | 0.76 | CHRNB2 (0.48) | ALDH1A1CYP2D6CYP3A4CYP2C19TSHR | |
| Hydrochloric Acid SCHEMBL16431012 | 0.76 | KCNJ1 (0.45) | TSHRACACAITGB3ITGA2B | |
| SCHEMBL17723444 | 0.75 | KCNJ1 (0.44) | ALDH1A1CYP2D6CYP3A4CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170275298-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | WUXI APPTEC (SHANGHAI) CO., LTD. (CN) | 2017-09-28 | — | — | US | disclosed |
| US-20170275298-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | WUXI APPTEC (SHANGHAI) CO., LTD. (CN) | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275298-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | KCNJ11, KCNJ1, KCNJ2 | ALDH1A1 1722/4885CYP2D6 3517/4885CYP3A4 4595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.